The long-term effects of cyclizine exposure during pregnancy

There is currently insufficient evidence to determine the long-term effects of cyclizine exposure during pregnancy. However, animal studies have suggested that cyclizine may cross the placenta and accumulate in the fetal brain, potentially causing neurodevelopmental effects. Additionally, case reports have linked cyclizine exposure during pregnancy to an increased risk of congenital anomalies, including cardiac defects. Given the lack of human data, cyclizine should be used during pregnancy only if the potential benefits outweigh the potential risks..More information

The role of cyclizine in fetal lung development

Cyclizine is a medication that is used to treat nausea and vomiting. It is also used to treat vertigo. Cyclizine is in a class of medications called antihistamines. It works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. Cyclizine is also used to help manage symptoms of inner ear problems (such as vertigo or Meniere’s disease). Cyclizine is available in generic form. Brand names of cyclizine include Marezine and Bonine.

Cyclizine is used to treat nausea, vomiting, and vertigo.

Cyclizine is also used to help manage symptoms of inner ear problems such as vertigo or Meniere’s disease.

Cyclizine is in a class of medications called antihistamines. It works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction.

Cyclizine is available in generic form. Brand names of cyclizine include Marezine and Bonine.

Cyclizine side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

confusion, hallucinations;

a light-headed feeling, like you might pass out;

seizure (convulsions);

fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out); or

jaundice (yellowing of your skin or eyes).

Common side effects may include:

drowsiness, feeling tired;

blurred vision;

dry mouth;

upset stomach; or

constipation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Cyclizine dosing information

Usual Adult Dose for Nausea/Vomiting:

25 to 50 mg orally 3 to 4 times a day as needed or 12.5 to 25 mg IM or IV 3 to 4 times a day

Comments:

-IM or IV doses may be given at intervals of 4 to 8 hours.

-Oral doses may be given at intervals of 6 to 8 hours.

-The total daily oral dose should not exceed 300 mg.

Uses:

-Relief of nausea and vomiting associated with certain conditions (including inner ear conditions, vestibular neuronitis, labyrinthitis);

-Prevention or treatment of nausea and vomiting associated with certain medical and surgical procedures (including radiotherapy and chemotherapy).

Usual Adult Dose for Vertigo:

25 to 50 mg orally 3 to 4 times a day or 12.5 to 25 mg IM or IV 3 to 4 times a day

Comments:

-IM or IV doses may be given at intervals of 4 to 8 hours.

-Oral doses may be given at intervals of 6 to 8 hours.

-The total daily oral dose should not exceed 300 mg.

Uses:

-Management of vertigo associated with certain inner ear conditions (vestibular neuronitis, labyrinthitis).

Usual Geriatric Dose for Nausea/Vomiting:

12.5 to 25 mg orally 3 to 4 times a day

Comments:

-Oral doses may be given at intervals of 6 to 8 hours.

-The total daily oral dose should not exceed 150 mg.

Uses:

-Relief of nausea and vomiting associated with certain conditions (including inner ear conditions, vestibular neuronitis, labyrinthitis);

-Prevention or treatment of nausea and vomiting associated with certain medical and surgical procedures (including radiotherapy and chemotherapy).

Usual Geriatric Dose for Vertigo:

12.5 to 25 mg orally 3 to 4 times a day

Comments:

-Oral doses may be given at intervals of 6 to 8 hours.

-The total daily oral dose should not exceed 150 mg.

Uses:

-Management of vertigo associated with certain inner ear conditions (vestibular neuronitis, labyrinthitis).

What other drugs will affect cyclizine?

Taking this medicine with other drugs that make you sleepy or slow your breathing can worsen these effects. Ask your doctor before taking cyclizine with a sleeping pill, narcotic pain medicine, muscle relaxer, medicine for anxiety or seizures, medicine for colds or allergy, antidepressant, or medicine for mental illness.

Other drugs may interact with cyclizine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Visit pregnancysicknesssuport.org.uk to learn more about cyclizine when pregnant. Disclaimer: We used this website as a reference for this blog post.